The “Cicero” of medicine: Aulus Cornelius Celsus / 中华疾病控制杂志

Aulus Cornelius Celsus (BC 25-AD 50), an ancient Roman Latin writer and compiler of encyclopedias, has been known as the “Cicero of medicine”. Celsus spread a lot of Greek scientific knowledge in beautiful Latin, published a treatise on medicine in a popular and concise way. Celsus published a book called De Medicina, which opened the history of modern pathology. This book had strong practicability and made a clear distinction between food therapy, drug therapy and surgery, which had a systematic influence on the development of western medicine. Celsus put forword primary prevention and held the view of that diet was the definitive treatment. He also discussed the empiricism and rationalism of medicine, which focused on individualized treatment to achieve the best results.

Effects of smoking on chronic obstructive pulmonary disease and respiratory symptoms / 中华疾病控制杂志

Objective To investigate the effects of smoking on chronic obstructive pulmonary disease(COPD) and respiratory symptoms. Methods A multi-stage, stratified cluster sampling strategy was used to select participants aged 40 or older in 5 surveillance points of Anhui Province. Questionnaires, body measurements and spirometry were used to collect data. Based on complex sampling design, Logistic regression model was conducted to analyze the effects of smoking on COPD and respiratory symptoms. Results The smokers who had smoked for ≥30 pack-years accounted for 13.9% (95% CI:10.3%-17.5%, P＜0.001) of the total population. And the smokers who had smoked for ≥40 years accounted for 8.5% (95% CI:6.7%-10.3%, P＜0.001) of the total population. On average, one smoker had smoked for 32.4 years (95% CI:31.2-33.5). Average daily cigarette consumption of daily smokers was 21.1 cigarettes (95% CI:19.6-22.7). As shown by multiple-variables Logistic regression analyses, the risk of COPD and respiratory symptoms increased with the increment of smoking pack-years and duration (all Ptrend <0.001). Conclusions Smoking was associated with COPD and respiratory symptoms. The risk of developing COPD and respiratory symptoms was greater with the increment of smoking pack-years and duration.

The founder of environment and disease theory：Hippocrates / 中华疾病控制杂志

Hippocrates (460-370 BC) is a famous doctor in ancient Greece and the founder of Western medicine. He is a “landmark” in the long history of human medicine and is considered as the first epidemiologist in history. He created the “Four Body Fluids” theory of medicine, freeing human medicine from theology and entering the natural medical model; His hard work on Airs, Waters, and Places, laid the epidemiological ideological foundation for more than 2 000 years; He was praised for his noble medical ethics, and his “Hippocrates Oath” has been extolled to today; he and his disciples have integrated the masterpiece “Hippocrates Collection” and passed on a generation of doctors. Therefore, Hippocrates is now known as the western “father of medicine”.

William Petty，founder of political arithmetic / 中华疾病控制杂志

@#William Petty ( 1623－1687) was a great 17th－century economist，statistician and one of the founders of the Ｒoyal Society． He put forward the concept of " political arithmetic" and used the method of " number，weight and measurement" to calculate and analyze the population and economic data of a country． His statistical methods laid the foundation for the development of statistics．

The pioneer of mental health: Philippe Pinel / 中华疾病控制杂志

Philippe Pinel (1745-1826) was a well-known French doctor and an outstanding mental health leader. Inspired by the ideas of the Enlightenment, he adopted “moral therapy” for the increasing mental patients in France. He took the lead in scientifically and effectively alleviating the current state of mental illness with the concept of humanitarian care, liberated mental patients, and opened the door for the mental health. Through field observation and meticulous statistical analysis, he classified mental illness into a more comprehensive scientific classification, guiding the direction for identifying, treating, and preventing mental illness, thus laying the theoretical and practical foundation. Many of his achievements about mental health have been used to this day, and he was known as the father of modern psychiatry.

Demand for non-occupational post-exposure prophylaxis services for HIV and associated factors among men who have sex with men in Liuzhou, Guangxi / 中华疾病控制杂志

Objective To analyze the demand for non-occupational post-exposure prophylaxis (nPEP) services and related influencing factors among men who have sex with men (MSM) in Liuzhou City, Guangxi Province. Methods MSM was recruited in Liuzhou City, Guangxi Province. Face-to-face survey was used to collect demographic information, knowledge about AIDS, history of high-risk behavior, knowledge and demand for nPEP services. 2 test was used to analyze the differences of demand for nPEP services among MSM with different characteristics and different high-risk behaviors. Log-binomial regression model was used to analyze the influencing factors of demand for nPEP services. Prevalence ratio and 95% confidence interval were calculated. Results 31.1% of MSM population had heard of nPEP service, and 61.6% of them needed the service after being informed of nPEP about its protective effect. 58.6% of MSM would spend money to buy nPEP service after high-risk behavior. Logistic regression analysis showed that the education level was university degree or above (PR=2.743, 95% CI: 1.996-3.450), the perception of the local MSM AIDS epidemic was not serious or unknown (PR=0.211, 95% CI: 0.112-0.294), and the number of temporary sexual partners in half a year was 2 or more (PR=3.642, 95% CI: 2.223-4.842), these subjects above were influencing factors of nPEP service demanded for respondents. Conclusions MSM population in Liuzhou area of Guangxi have a certain need for nPEP service. We should implement nPEP service as soon as possible in accordance with local conditions, and strengthen the corresponding propaganda to reduce the harm of AIDS to MSM population.

The leader of American public health: Edward Jarvis / 中华疾病控制杂志

Edward Jarvis (1803-1884) was a famous clinician of Harvard Medical School, excellent social statistician and outstanding public health leader. He applied social statistics to improve the American census system, changed the status of mental illness in America, and pioneered family group psychotherapy. Jarvis attached great importance to disease prevention, advocated prevention and treatment of diseases from the perspective of disease prevention, strengthen health construction, and promoted the development of public health in America.

New China’s public health practice has been brilliant for 70 years / 中华疾病控制杂志

Strive for 70 years, strive for a new era. Under the leadership of the Communist Party of China, China’s public health adheres to the System of Socialism with Chinese Characteristics, and always implements the policy of putting prevention first. Since the founding of the People’s Republic of China, after the reform and opening up, a public health system with a combination of epidemic prevention and disease prevention with Chinese characteristics has been established, and a public health undertaking with Chinese characteristics has been created. Especially since the 18th National Congress of the Communist Party of China, China’s public health has spurred the slogan of “Implementing a Healthy China Strategy” in the new era, and fully promoted the “the Plan for Health China 2030” to lay a solid foundation for the Chinese dream of realizing the great rejuvenation of the Chinese nation.

Practice with erudition, patriotism with sincerity: in memory of Wu Lien Teh, a plague fighter and pioneer of public health in China / 中华疾病控制杂志

Wu Lien Teh (1879-1960), a world-renowned health and epidemic prevention expert, was a pioneer in public health and medical education in China. With his scientific ideas and methods, he extinguished the plague epidemic in northeast China which shocked the world at the beginning of the 20th century. He proposed and enriched the theory of pneumonic plague, and his work marked a milestone in the world’s plague prevention and treatment. He established a scientific health and epidemic prevention system in China, promoted the reform of medical education, established modern medical institutes and hospitals, founded the Chinese Medical Association, helped reclaim the right of port quarantine, strengthened the anti-opium campaign, and promoted cultural exchanges between Chinese and western medicine. He was knowledgeable and far-sighted, and committed to the practice and research of infectious disease prevention and treatment, promoting the development of China’s public health, which has a far-reaching impact on China and the world.

Poisson distribution and the development of probability theory: Siméon Denis Poisson / 中华疾病控制杂志

Siméon Denis Poisson (1781-1840) was a famous French mathematician, physicist and founder of statistical theory. He established the Poisson distribution model through the criminal trial cases and solved many random phenomena in natural science and social science. He also introduced birth statistics, Poisson's inference theory, Laplace's theorem and error theory, law of large numbers and judgment probability and other related theories. Poisson promoted the development of probability theory in the 19th century and opened up a new trend of physics from experimental research to theoretical research.

Daniel Bernoulli, the brick-picker of epidemiology / 中华疾病控制杂志

Daniel Bernoulli (1700-1782) was a famous physicist and mathematician in the 18th century. He made a compelling statistical case for smallpox vaccination. He made important contributions to the knowledge of probability theory and calculus, and was the first person to put forward the question of statistical hypothesis test. At the same time, he applied probability theory to practical problems such as the ratio of male to female births. In the development of epidemiology and biostatistics, he seems to be a brick picker, moving indispensable cornerstone.

Founder of analytical probability theory: Pierre Simon Laplace / 中华疾病控制杂志

Pierre Simon Laplace (1749-1827), known as "Newton of France", was the founder of analytical probability theory, invented Laplace’s law and integrated celestial mechanics. He promoted the development of analytical probability theory, led classical probability theory to follow the world trend, and also laid a solid foundation for the emergence of modern probability theory. He actively extended the application of probability theory to the fields of decision-making theory and maritime insurance. Laplace's law was not only applied in the field of physics, but also in the field of medicine, especially in cardiovascular, urology, anorectal and other disciplines, which is crucial for the interpretation of clinical symptoms and the selection of treatment methods. Laplace also used calculus to explore classical mechanics, successfully explained Newton's legacy of multi-planetary interaction.

Research progress in infodemiology study / 中华疾病控制杂志

Web technologies, such as search engines and social media, have provided an opportunity for the management of user generated data in real time. Through the analysis of these web-based data, people can understand the health issues of concern, which can be used for the prediction of the epidemic of infectious diseases and the monitoring of chronic non-communicable diseases. The emergence of Infodemiology, also known as Information Epidemiology, aims to study the occurrence, distribution and influencing factors of health information from electronic medium, so as to raise awareness of disease and health problems among people, and provide the basis for the formulation of disease prevention and control strategies. This review summarizes the research progress in Infodemiology.

A Promoter of the Metropolitan Health Bill: Stephen Smith / 中华疾病控制杂志

Stephen Smith (1823-1922) was an American surgeon, an editor of the New York Journal of Medicine and outstanding public health leader. He founded the American Public Health Association, and used the American Medical Times as a position to alert people to efforts and improve the living environment. His unremitting efforts contributed greatly to the enactment of the Metropolitan Health Bill in USA. He has made significant contributions to public health legislation and improving public health in USA. He is also synonymous with longevity, using his 99-year-old to demonstrate the importance of preventing disease for longevity.

Situation analysis of mental disorders in females with systemic lupus erythematosus / 中华疾病控制杂志

Objective To study the influences of mental disorders on female systemic lupus erythematosus(SLE)and analyze the factors. Methods We used symptom check list -90 (SCL-90) as a basis for judging mental disorders disease activity. Disease activity, social support and depreciation - discrimination were used as possible influencing factors. Social support and discomfort – discrimination were possible influencing factors. Multivariate unconditional logistic regression model was used to analyze the influencing factors of mental disorders. Results The total score of SCL-90 of patients with female SLE was significantly higher than that of norm models ［(136.39±48.66) vs (129.96±38.76)］ (P<0.05), in 289 SLE patients, the number of patients with mental disorders was 128 (44.3%). High monthly income(OR=0.770, 95% CI:0.604-0.981, P=0.034) was a protective factor for mental disorders. High disease activity (OR=1.792, 95% CI:1.023-3.138, P=0.042)and high discomfort–discrimination (OR=1.100, 95% CI:1.035-1.169, P=0.002)were risk factors for mental disorders. Conclusions Female SLE patients have a higher risk of mental disorders than the general population. And eliminating self-depreciation, reducing social discrimination, active employment, increasing monthly income, standardizing treatment and reducing disease activity may effectively alleviate mental disorders in SLE patients.

Establishment of voluntary notification system for tuberculosis epidemic situation : Arthur Newsholme / 中华疾病控制杂志

Arthur Newsholme (1857-1943) was a British physician and medical health officer. He applied statistical methods to analyze the causes of disease, established voluntary reporting system of tuberculosis, revealed truth about relationship between high infant mortality and environmental health in the UK, and launched maternity and child welfare schemes, tuberculosis medical services and special service for venereal diseases. Although he grew up in religious environment, he has always used scientific methods to benefit human health，promoted and spread public health.

American public health promoter: William Henry·Welch / 中华疾病控制杂志

William Henry·Welch (1850-1934) was a famous American pathologist, bacteriologist and medical school administrator. He introduced European exquisite experimental technology, frontier bacteriology theory and innovative scientific research thinking into American medical field, promoted American health reform, and promoted the development of public health in the United States. At the same time, Welch founded the Johns Hopkins School of Hygiene and Public Health, the first public health school in the United States, and provided a blueprint for world public health education.

Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Glaucoma is a major cause of irreversible blindness worldwide. There is evidence showing that a subset of the disease is genetically determined. In this study, we screened for mutations in chromosome 1q-linked open-angle glaucoma (GLC1A) in a Chinese family with primary open-angle glaucoma (POAG).</p><p><b>METHODS</b>A total of 23 members from five generations of a family were enrolled and underwent thorough ophthalmologic examinations. In addition, 200 unrelated healthy Chinese controls were also recruited as normal control. GLC1A gene was amplified by polymerase chain reaction, and DNA sequencing was performed to screen for mutations.</p><p><b>RESULTS</b>Six members were diagnosed as POAG, with severe clinical manifestations, and history of high intraocular pressures. The mean age of disease onset was 26.3 years. However, the others were asymptomatic. In six affected and three asymptomatic members, gene sequencing revealed a mutation c.C1456T in exon 3 of myocilin gene (MYOC). Furthermore, we also identified a novel mutation c.G322A in beta-1,4-galactosyltransferase 3 (B4GALT3) gene in all six affected and three asymptomatic members, which was not reported previously in POAG patients. The two newly identified variants were absent in other family members as well as controls.</p><p><b>CONCLUSION</b>The mutations c.1456C < T (p.L486F) in MYOC and c.322G < A (p.V108I) in B4GALT3 are likely responsible for the pathogenesis of POAG in this family.</p>

Study on the relationship between college students' physical quality and the quality of sleep / 中华流行病学杂志

Objective The author wants to investigate the relationship between college students' physical quality and the quality of sleep.Methods Stratified cluster sampling method is used,and invites a total of 2981 Anhui college students to take part in the questionnaire study,the Pittsburgh sleep quality index (PSQI) and physical test,in order to survey the sleep quality and physical quality of college students.The physical quality and sleep quality are analyzed by the multiple factor non conditional logistic regression analysis methods.Results PSQI scores of the 2744 students are (5.378 ± 2.492),477 people (17.4％) have poor sleep quality.The endurance,speed,strength quality scores are (75.850 ± 13.279),(69.760 ± 16.422),(66.278 ± 18.709) points.Logistic regression analysis shows that excellent endurance (OR=0.418) is a protective factor of sleep quality.Conclusion The improvement of endurance may improve sleep quality.

TREK1 potassium channels and depression / 药学学报

Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.